Robert Panacci
Written By: Julia Brabant, August 2025Advocacy Born From Adversity: Robert Panacci’s Story
When doctors diagnosed Arizona’s Robert Panacci with Stage 3 pancreatic cancer, they told him that, with chemotherapy, radiation and surgery, he might have another year left to live. Now, five years later, Robert has a new care team in place, and he’s also become an outspoken advocate for the cause, using his voice and connections to expand research, encourage collaboration, and, ultimately, deliver hope to those facing a similar diagnosis.
I refused to believe this was going to kill me.
Diagnosed in October 2019, Robert first sought treatment after experiencing ongoing pain in the middle of his back. He went to see his general practitioner, who conducted an ultrasound that revealed a mass. Recognizing the urgency of Robert’s situation, his GP had him come back to the office within 24 hours and then promptly sent him across the hall to see a surgeon.
The surgeon ordered a CT scan, which identified the presence of a 3.5-centimeter tumor on the head of Robert’s pancreas. The surgeon sent Robert straight to an oncologist who confirmed that, given the size and location of Robert’s tumor, which was near a major artery, his situation “didn’t look good.”
A biopsy confirmed the presence of cancer, with the oncologist recommending that Robert undergo chemotherapy and radiation so that surgery may become possible. If so, the doctor told Robert, he might have another year left.
Undeterred, Robert sought a second opinion at the Mayo Clinic in Phoenix, Arizona. There, doctors recommended a similar treatment plan of chemotherapy, radiation and surgery. However, they had a more optimistic outlook than his original team, suggesting that if Robert were able to have surgery, he’d have a “very good chance at survival.”
There’s a lot to be said for the power of hope. With hope and a plan, almost anything is possible.
Encouraged, Robert began chemo using FOLFIRINOX, a combination of cancer drugs often used to treat advanced pancreatic cancer. He went through 12 rounds, spending a full day on drip and then an additional 48 hours with a portable pack. He navigated the first few rounds relatively well, but soon, neuropathy, fatigue, appetite loss and nausea kicked in. He began taking another prescription drug to combat the nausea, but it caused him considerable anxiety and edginess until he found an alternative.
While Robert’s side effects were tough to tolerate, he was lucky in that he had a strong support system lifting him up along the way, including his wife, Stephanie, his four children, Alexandra, Olivia, Allie and Aidan, and his parents and large family in Toronto, Canada.
With his family and loved ones by his side, Robert completed chemo, with his doctors determining that his tumor was shrinking and his CA-19-9 numbers were falling. He then moved on to proton radiation, a precise – and painful – type of radiation therapy that uses protons to target and destroy cancer cells and prevent them from multiplying. After five sessions, his team determined Robert’s tumor had receded far enough away from his artery to move forward with surgery. He ended up having a Whipple procedure June 30, 2020, during the heart of the COVID-19 pandemic, and the surgery proved successful, resulting in the removal of his tumor and a chance at life that his initial doctors didn’t think was possible.
My advice is, always get that second opinion. Always determine if there’s a clinical trial available. And take care of yourself, regardless of how much time you think you have, live like you believe tomorrow is coming and most importantly, enjoy every day.
Robert’s successful surgery marked a turning point, not only in his cancer journey but in his outlook. While surviving Stage 3 pancreatic cancer gave him more time to spend with loved ones, it also inspired him to start making a difference for others. Part of what drove him was the reality of the toll cancer takes on Americans, with the projected number of annual cancer deaths weighing heavily on his mind.
About two years after his Whipple surgery, Robert signed on to participate in a walk hosted by the Pancreatic Cancer Action Network (PanCan). The organization, like many nonprofits, was seeing a notable decline in donations and volunteers in the wake of the pandemic, so Robert became increasingly involved in its advocacy efforts by stepping into a volunteer role and sharing his story with survivors.
As his comfort level increased, so, too, did his communications, and Robert began sharing his story via LinkedIn and other social media networks, where it caught the attention of the venture capitalist behind CANCER FUND. The initiative backs companies focused on finding and developing cancer solutions, including early detection methods and diagnostic tools. Robert now serves as the Community Engagement leader for CANCER FUND, and he’s also become increasingly ingrained in the cancer community in Arizona, specifically, a place he believes is at the forefront of cancer research today.
“Arizona has a remarkable med and biotech community,” Robert said, noting that his advocacy got him in the door of several local labs and research facilities, where he discovered that a substantial percentage of cancer clinical trials are taking place within state lines. He was also inspired by the number of organizations making progress in developing new diagnostic tools and detection methods, noting that CANCER FUND had no shortage of companies in the pipeline seeking funding for their own research efforts.
Robert’s advocacy has also helped shape his perspective on what today’s medical professionals are doing right when it comes to treating pancreatic cancer – and where they could stand to improve. More specifically, he feels that researchers, doctors and drug companies need to collaborate more and compete less to avoid slowing the progress today’s patients need.
This perspective also drew Robert to the work of Lou Weisbach, a successful Chicago-based businessman behind the concept of an “American Center for Cures.” Weisbach’s vision involves having doctors and business leaders work in tandem to improve options and outcomes for people with specific diseases, such as diabetes or cancer. Robert is inspired by Weisbach’s strategy for developing a model where the medtech community can work together toward a defined end goal, such as advancing a particular treatment option from the lab research stage to the human testing phase, or taking a particular treatment from a clinical trial all the way through FDA approval. Robert is actively championing the proposed model, helping drive necessary changes in terms of where state and federal funding goes and what health issues the nation considers to be priorities.
Robert’s advocacy also motivated him to research potential factors that might have caused or contributed to his own cancer diagnosis. His father had battled prostate cancer, which prompted Robert to undergo genetic testing. The results revealed that he carries the BRCA2 gene mutation, a genetic marker known to elevate the risk for several types of cancer, including pancreatic and breast cancers. Several of his blood relatives followed in his footsteps, wanting to get a better sense of their own potential hereditary risks.
Robert is also helping spread the word about some common misconceptions many people share about pancreatic cancer, hoping that raising awareness will help people recognize that a diagnosis is not a death sentence and that there are opportunities for treatment.
“There’s a lot being done right now, especially with clinical trials,” he said, noting that he also feels optimistic about current research efforts involving KRAS inhibitors, targeted therapies and liquid biopsies. “My advice is, always get that second opinion. Always determine if there’s a clinical trial available. And take care of yourself, regardless of how much time you think you have, live like you believe tomorrow is coming and most importantly, enjoy every day.”
Robert also highlights the importance of maintaining a positive attitude amid – and after – treatment.
“I refused to believe this was going to kill me,” he said. He is encouraged by the empathetic, intelligent and dedicated field of doctors, researchers and all of their support networks working tirelessly to change the usual prognosis of pancreatic cancer to one where patients can hope for a better tomorrow.
“There’s a lot to be said for the power of hope. With hope and a plan, almost anything is possible.”
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