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Adolescent Obesity Could Result In Up To Four-Fold Increased Risk of Getting Pancreatic Cancer At Adulthood
November 12, 2018
Press Release: Wiley
Edited For Style and Length
Pancreatic cancer is the sixth most common cause of cancer-related deaths in the world and third in the United States.
Studies have linked adult obesity with an increased risk for its occurrence. To uncover any potential associations with adolescent weight, Zohar Levi, MD, of Rabin Medical Center and Tel Aviv University, and his colleagues analyzed 1,087,358 Israeli Jewish men and 707,212 Jewish women who underwent a compulsory physical examination between the ages of 16 and 19 years from 1967 to 2002. Pancreatic cancer incidence through 2012 was identified by linkage to the Israeli National Cancer Registry.
Among men, high-normal BMI (?75th to <85th percentile) and overweight (85th to <95th percentile) were associated with 49 percent and 97 percent higher risks for cancer, respectively, compared with low-normal BMI (?5th to <25th percentile).
“The overall population attributable fraction of pancreatic cancer due to adolescent overweight and obesity was 11 percent among this Israeli Jewish population,” said Dr. Levi.
An accompanying editorial by Chanan Meydan, MD, of the Mayanei Hayeshua Medical Center in Israel, highlights systemic inflammation caused by obesity as a potential driver behind the development of pancreatic cancer.